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AFFECT-EU

DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY

The AFFECT-EU project was initiated by Renate Schnabel a member of the AF-SCREEN steering committee, who was the Chief Investigator in the application for a Horizon-2020 EU grant which included many members of AF-SCREEN.

The project is an EU-funded consortium including 25 partner from academia and industry. AFFECT-EU`s major goal is the development of a risk-based, accurate, and ready for implementation atrial fibrillation screening algorithm, using digital devices, for early AF detection in the community. AFFECT-EU will fill in the AF screening knowledge gaps by integrating information from independent studies entering the project. These data will be used to implement a risk-based AF screening approach and to provide evidence on the superiority of AF screening using a robust community screening strategy for reducing AF-related morbidity and mortality

The AFFECT-EU

Coordinator: Renate Schnabel

University Medical Center Hamburg-Eppendorf (UKE)

Martinistraße 52, 20246 Hamburg, Germany

LOOP

Detection of Atrial Fibrillation in Patients With Recent Stroke or TIA: Validity of Automated Loop-recording (Rtest) Compared to Holter Recording and Predictive Value of Short Runs of Atrial Fibrillation and an Excess Supraventricular Extra Systoles for a New Stroke

The LOOP trial aims to clarify whether stroke can be prevented by monitoring the heart rhythm with a small device (called a loop recorder). The recorder is placed under the skin on the front of the chest, which allows monitoring of the heart rhythm 24-hours a day 7 days a week.
www.loop-study.dk

Incident AF – PREVEND (Data of)

Incidence of Atrial Fibrillation and Relationship With Cardiovascular Events, Heart Failure, and Mortality (Netherlands)

This study investigated the incidence of AF in a contemporary cohort in the Netherlands, together with comorbidities associated with AF and associations of AF with cardiovascular outcomes.

In 8265 participants of the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study in Groningenm The Netherlands, incident AF was ascertained on hospital – and study electrocardiograms.
http://content.onlinejacc.org/article.aspx?articleid=2430618#tab1

D2AF

Detecting and Diagnosing Atrial Fibrillation (D2AF): study protocol for a cluster randomised controlled trial

This study aims to determine the yield of case-finding for atrial fibrillation in primary care patients. In addition, it will determine the diagnostic accuracy of three different case-finding methods.
http://www.trialsjournal.com/content/16/1/478
http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4914

Opportunistic Screening for Atrial Fibrillation in a Rural Area (Ireland)

Opportunistic AF screening in a rural environment identified a substantial number of new cases, although less than in previous screening studies.
http://qjmed.oxfordjournals.org/content/early/2016/01/27/qjmed.hcw011.

Assessment of remote heart rhythm sampling using the AliveCor® heart monitor to screen for atrial fibrillation

It is proposed that the AliveCor system will be trialled as a means of identifying patients with AF in the community in order to facilitate earlier diagnosis and treatment to reduce the incidence of major cardiovascular events (notably stroke).
http://www.hra.nhs.uk/news/research-summaries/alivecor-2/
http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=19952

PIAAF-Home (Screen AF)

Program for the Identification of “Actionable” Atrial Fibrillation (PIAAF): In the Home-Based Setting

The Screen-AF team will investigate new portable devices to screen patients for AF in their own home.  Through the Screen-AF study we hope to establish a practical and cost effective screening strategy where a patient could test for AF without disrupting their everyday routines and not have to go to labs or doctors’ offices to get testing done.
PIAAF-Home (Screen AF) – ClinicalTrials.gov