
DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY
The AFFECT-EU project was initiated by Renate Schnabel a member of the AF-SCREEN steering committee, who was the Chief Investigator in the application for a Horizon-2020 EU grant which included many members of AF-SCREEN.
The project is an EU-funded consortium including 25 partner from academia and industry. AFFECT-EU`s major goal is the development of a risk-based, accurate, and ready for implementation atrial fibrillation screening algorithm, using digital devices, for early AF detection in the community. AFFECT-EU will fill in the AF screening knowledge gaps by integrating information from independent studies entering the project. These data will be used to implement a risk-based AF screening approach and to provide evidence on the superiority of AF screening using a robust community screening strategy for reducing AF-related morbidity and mortality
Coordinator: Renate Schnabel
University Medical Center Hamburg-Eppendorf (UKE)
Martinistraße 52, 20246 Hamburg, Germany
Authors | Title | Publication | Pages | ISSN |
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Schnabel RB, Ameri P, Siller-Matula JM, Diemberger I, Gwechenberger M, Pecen L, Manu MC, Souza J, De Caterina R, Kirchhof P. | Outcomes of patients with atrial fibrillation on oral anticoagulation with and without heart failure: the ETNA-AF-Europe registry. | Europace. 2023 Sep 15:euad280. | ||
Sposato Luciano et al. | Towards a new classification of atrial fibrillation detected after a stroke or a transient ischaemic attack. | Lancet Neurology | ||
Schnabel RB, Ameri P, Siller-Matula JM, Diemberger I, Gwechenberger M, Pecen L, Manu MC, Souza J, De Caterina R, Kirchhof P. | Outcomes of patients with atrial fibrillation on oral anticoagulation with and without heart failure: the ETNA-AF-Europe registry. | Europace. 2023 Sep 15:euad280. | ||
Lucas Yixi Xing, Søren Zöga Diederichsen, Søren Højberg, Derk W Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S Olesen, Axel Brandes, Lars Køber, Ketil Jørgen Haugan, Jesper Hastrup Svendsen | Effects of systematic atrial fibrillation screening according to N-terminal pro-B-type natriuretic peptide: a secondary analysis of the randomized LOOP study. | |||
Xing, L.Y., Diederichsen, S.Z., Højberg, S., Krieger, D.W., Graff, C., Olesen, M.S., Nielsen, J.B., Brandes, A., Køber, L., Haugan, K.J., and Svendsen, J.H. | Electrocardiographic Markers of Subclinical Atrial Fibrillation Detected by Implantable Loop Recorder: Insights from the LOOP Study. | Europace , 2023 | ||
Börschel CS, Geelhoed B, Niiranen T, Camen S, Donati MB, Havulinna AS, Gianfagna F, Palosaari T, Jousilahti P, Kontto J, Vartiainen E, Ojeda FM, den Ruijter HM, Costanzo S, de Gaetano G, Di Castelnuovo A, Linneberg A, Vishram-Nielsen JK, Løchen ML, Koenig W, Jørgensen T, Kuulasmaa K, Blankenberg S, Iacoviello L, Zeller T, Söderberg S, Salomaa V, Schnabel RB. | Risk prediction of atrial fibrillation and its complications in the community using hs troponin I. | Eur. J. Clin. Invest., 2023 | ISSN 0014-2972 | |
Jelena Kornej, Honghuang Lin, Ludovic Trinquart, Corban R Jackson, Darae Ko, Emelia J Benjamin, Sarah R Preis | Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study. | J Am Heart Assoc, 2023 | ISSN 2047-9980 | |
Toprak B, Brandt S, Brederecke J, Gianfagna F, Vishram-Nielsen JKK, Ojeda FM, Costanzo S, Börschel CS, Söderberg S, Katsoularis I, Camen S, Vartiainen E, Donati MB, Kontto J, Bobak M, Mathiesen EB, Linneberg A, Koenig W, Løchen ML, Di Castelnuovo A, Blankenberg S, de Gaetano G, Kuulasmaa K, Salomaa V, Iacoviello L, Niiranen T, Zeller T, Schnabel RB. | Exploring the incremental utility of circulating biomarkers for robust risk prediction of incident atrial fibrillation in European cohorts using regressions and modern machine learning methods. | Europace, 2023 | ISSN 1532-2092 | |
Börschel CS, Ortega-Alonso A, Havulinna AS, Jousilahti P, Salmi M, Jalkanen S, Veikko S, Niiranen T, Schnabel RB. | Inflammatory proteomics profiling for prediction of incident atrial fibrillation. | Heart, 2023 | ISSN 1355-6037 | |
Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D | Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. | Europace, 2023 | ISSN 1099-5129 | |
Sílvia C Mendonça, Duncan Edwards, Jenny Lund, Catherine Saunders and Jonathan Mant | Progression of stroke risk in atrial fibrillation: cohort study in general practice. | British Journal of General Practice, 2023 | ISSN 0960-1643 | |
Joonatan Palmu, Christin S. Börschel, Alfredo Ortega-Alonso, Lajos Markó, Mike Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel | Gut microbiome and atrial fibrillation – results from a large population-based study. | eBioMedicine, 2023 | ISSN 2352-3964 | |
Vermunicht P, Grecu M, Deharo JC, Buckley CM, Palà E, Mairesse GH, Farkowski MM, Bergonti M, Pürerfellner H, Hanson CL, Neubeck L. | General practitioners’ perceptions on opportunistic single-time point screening for atrial fibrillation: A European quantitative survey. | Frontiers in Cardiovascular Medicine. 2023 Feb 15;10:1112561. | ||
Pecha, S., Ismaili, D., Geelhoed, B., Knaut, M., Reichenspurner, H., Eschenhagen, T., Schnabel, R. B., Christ, T., & Ravens, U.., (2023). | Resting membrane potential is less negative in trabeculae from right atrial appendages of women, but action potential duration does not shorten with age. Journal of Molecular and Cellular Cardiology, VOLUME 176, P1-10, MARCH 2023 | |||
Xing, L. Y., Diederichsen, S. Z., Højberg, S., Krieger, D. W., Graff, C., Olesen, M. S., … & Svendsen, J. H. (2022) | Screening for atrial fibrillation to prevent stroke in elderly individuals with or without preexisting cardiovascular disease: A post hoc analysis of the randomized LOOP study. International Journal of Cardiology 370, 197-203. | |||
Diederichsen SZ, Frederiksen KS, Xing LY, et al. | Severity and Etiology of Incident Stroke in Patients Screened for Atrial Fibrillation vs Usual Care and the Impact of Prior Stroke: A Post Hoc Analysis of the LOOP Randomized Clinical Trial. | Jama Neurology, 2022;79(10):997–1004 | ||
McIntyre W.F. et al | Screening for atrial fibrillation to prevent stroke: a meta-analysis. | European Heart Journal, Volume 2, Issue 4, July 2022 | ||
Xing LY, Diederichsen SZ, Højberg S, Krieger DW, Graff C, Olesen MS, Brandes A, Køber L, Haugan KJ, Svendsen JH. | Systolic Blood Pressure and Effects of Screening for Atrial Fibrillation With Long-Term Continuous Monitoring (a LOOP Substudy). | Hypertension, 2022;79:2081–2090 | ||
Palà E, Bustamante A, Pagola J, Juega J, Francisco-Pascual J, Penalba A, Rodriguez M, De Lera Alfonso M, Arenillas JF, Cabezas JA, Pérez-Sánchez S. | Blood-Based Biomarkers to Search for Atrial Fibrillation in High-Risk Asymptomatic Individuals and Cryptogenic Stroke Patients. | Frontiers in cardiovascular medicine, 2022 Jul 4;9:908053 | ||
Engler D, Hanson CL, Desteghe L, Boriani G, Diederichsen SZ, Freedman B, Palà E, Potpara TS, Witt H, Heidbuchel H, Neubeck L. | Feasible approaches and implementation challenges to atrial fibrillation screening: a qualitative study of stakeholder views in 11 European countries. | the BMJ open, 2022 Jun 1;12(6):e059156. | ||
Ohlrogge AH, Brederecke J, Ojeda FM, Pecha S, Börschel CS, Conradi L, Rimkus V, Blankenberg S, Zeller T, Schnabel RB. | The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study. | Frontiers in Nutrition. 2022 May 10;9 | ||
Valenti AC, Albini A, Imberti JF, Vitolo M, Bonini N, Lattanzi G, Schnabel RB, Boriani G. | Clinical Profile, Arrhythmias, and Adverse Cardiac Outcomes in Emery-Dreifuss Muscular Dystrophies: A Systematic Review of the Literature. | Biology. 2022 Mar 30;11(4):530. | ||
Rivard L, Friberg L, Conen D, Healey JS, Berge T, Boriani G, Brandes A, Calkins H, Camm AJ, Yee Chen L, Lluis Clua Espuny J. | Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration. | Circulation | ||
Assum I, Krause J, Scheinhardt MO, Müller C, Hammer E, Börschel CS, Völker U, Conradi L, Geelhoed B, Zeller T, Schnabel RB | Tissue-specific multi-omics analysis of atrial fibrillation. Nature | |||
Sarah Hoare, Alison Powell, Rakesh Modi, Natalie Armstrong, Simon Griffin, Jonathan Mant, Jenni Burt | Why do people take part in atrial fibrillation screening? Qualitative interview study in English primary care. BMJ Open, 2022 | ISSN 2044-6055 | ||
Aittokallio J, Kauko A, Vaura F, Salomaa V, Kiviniemi T; FinnGen; Schnabel RB, Niiranen T. | Polygenic Risk Scores for Predicting Adverse Outcomes After Coronary Revascularization. Am. J. Cardiol., 2022 | ISSN 0002-9149 | ||
Camen S, Csengeri D, Geelhoed B, Niiranen T, Gianfagna F, Vishram-Nielsen JK, Costanzo S, Söderberg S, Vartiainen E, Börschel CS, Donati MB, Løchen ML, Ojeda FM, Kontto J, Mathiesen EB, Jensen S, Koenig W, Kee F, de Gaetano G, Zeller T, Jørgensen T, Tunstall-Pedoe H, Blankenberg S, Kuulasmaa K, Linneberg A, Salomaa V, Iacoviello L, Schnabel RB. | Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation. | J. Am. Heart Assoc., 2022 | ISSN 2047-9980 | |
Oskarsson V, Eliasson M, Salomaa V, Reinikainen J, Männistö S, Palmieri L, Donfrancesco C, Sans S, Costanzo S, de Gaetano G, Iacoviello L, Veronesi G, Ferrario MM, Padro T, Thorand B, Huth C, Zeller T, Blankenberg S, Anderson AS, Tunstall-Pedoe H, Kuulasmaa K, Söderberg S; BiomarCaRE investigators. | Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. Br J Nutr, 2022 | ISSN 0007-1145 | ||
Jelena Kornej, Maha A Qadan, Mona Alotaibi, David R Van Wagoner, Jeramie D Watrous, Ludovic Trinquart, Sarah R Preis, Darae Ko, Mohit Jain, Emelia J Benjamin, Susan Cheng, Honghuang Lin | The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study. Scientific Reports, 2022 | ISSN 2045-2322 | ||
Rosberg V, Vishram-Nielsen JK, Kristensen AMD, Pareek M, Sehested TSG, Nilsson PM, Linneberg A, Palmieri L, Giampaoli S, Donfrancesco C, Kee F, Mancia G, Cesana G, Veronesi G, Grassi G, Kuulasmaa K, Salomaa V, Palosaari T, Sans S, Ferrieres J, Dallongeville J, Söderberg S, Moitry M, Drygas W, Tamosiunas A, Peters A, Brenner H, Schöttker B, Grimsgaard S, Biering-Sørensen T, Olsen MH. | Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project. Prev Med Rep, 2022 | ISSN 2211-3355 | ||
Alison Powell, Sarah Hoars, Rakesh Modi, Kate Williams, Andrew Dymond, Cheryl Chapman, Simon Griffon, Jonathan Mant, Jenni Burt | How to embed qualitative research in trials: insights from the feasibility study of the SAFER trial programme. Trials, 2022 | ISSN 1745-6215 | ||
Kate Williams, Rakesh Modi, Andrew Dymond, Sarah Hoare. Alison Powell, Jenni Burt, Duncan Edwards, Jenny Lund, Rachel Johnson, Trudie Lobban, Mark Lown, Michael Sweeting, H Thom, Stephen Kaptoge, Francesco Fusco, Stephen Morris, Gregory Lip, Natalie Armstrong, Martin Cowie, David Fitzmaurice, Ben Freedman, Simon Griffin, Stephen Sutton, Richard Hobbs, Richard McManus, Jonathan Mant | Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial. BMJ Open, 2022 | ISSN 2044-6055 | ||
Rehm M, Rothenbacher D, Iacoviello L, Costanzo S, Tunstall-Pedoe H, Fitton CA, Söderberg S, Hultdin J, Salomaa V, Jousilahti P, Palosaari T, Kuulasmaa K, Waldeyer C, Schnabel RB, Zeller T, Blankenberg S, Koenig W; BiomarCaRE Consortium | Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project. ESC Heart Fail., 2022 | ISSN 0195-668X | ||
Sujana C, Salomaa V, Kee F, Seissler J, Jousilahti P, Neville C, Then C, Koenig W, Kuulasmaa K, Reinikainen J, Blankenberg S, Zeller T, Herder C, Mansmann U, Peters A, Thorand B; BiomarCaRE Consortium. | Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium. Cardiovascular Diabetology, 2022 | ISSN 1475-2840 | ||
ESC Cardiovasc Risk Collaboration, SCORE2 Working Group. | SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal. 2021 Jul 1;42(25):2439-54. | |||
Dora Csengeri, Ngoc-Anh Sprünker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Steen M Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Løchen, Frank Kee, Jukka Kontto, Ellisiv B Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jørgensen, Kari K | Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. European Heart Journal, 2021 | ISSN 0195-668X | ||
Christin S Börschel, Amelie H Ohlrogge, Bastiaan Geelhoed, Teemu Niiranen, Aki S Havulinna, Tarja Palosaari, Pekka Jousilahti, Michiel Rienstra, Pim van der Harst, Stefan Blankenberg, Tanja Zeller, Veikko Salomaa, Renate B Schnabel | Risk prediction of atrial fibrillation in the community combining biomarkers and genetics. EP Europace, 2021 | ISSN 1099-5129 | ||
Vuori MA, Reinikainen J, Söderberg S, Bergdahl E, Jousilahti P, Tunstall-Pedoe H, Zeller T, Westermann D, Sans S, Linneberg A, Iacoviello L, Costanzo S, Salomaa V, Blankenberg S, Kuulasmaa K, Niiranen TJ. | Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium. Cardiovascular Diabetology, 2021 | ISSN 1475-2840 | ||
Daniel Engler, Hein Heidbuchel, Renate B Schnabel | Digital, risk-based screening for atrial fibrillation in the European community—the AFFECT-EU project funded by the European Union. | European Heart Journal, 2021 | ISSN 0195-668X | |
Sujana C, Salomaa V, Kee F, Costanzo S, Söderberg S, Jordan J, Jousilahti P, Neville C, Iacoviello L, Oskarsson V, Westermann D, Koenig W, Kuulasmaa K, Reinikainen J, Blankenberg S, B; BiomarCaRE Consortium. Zeller T, Herder C, Mansmann U, Peters A, Thorand | Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium. Diabetes Care, 2021 | ISSN 0149-5992 | ||
Ben Freedman, Gerhard Hindricks, Amitava Banerjee, Adrian Baranchuk, Chi Keong Ching, Xin Du, Donna Fitzsimons, Jeff S. Healey, Takanori Ikeda, Trudie C. A. Lobban, Amam Mbakwem, Calambur Narasimhan, Lis Neubeck, Peter Noseworthy, Daniel M. Philbin, Fausto J. Pinto, Joselyn Rwebembera, Renate B. Schnabel, Jesper Hastrup Svendsen, Luis Aguinaga, Elena Arbelo, Michael Böhm, Hasan Ali Farhan, F. D. | World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update. Global Heart, Issue 16/1, 2021 | ISSN 2211-8179 | ||
Larissa Fabritz, Harry J G M Crijns, Eduard Guasch, Andreas Goette, Karl Georg Häusler, Dipak Kotecha, Thorsten Lewalter, Christian Meyer, Tatjana S Potpara, Michiel Rienstra, Renate B Schnabel, Stephan Willems, Guenter Breithardt, A John Camm, Anthony Chan, Winnie Chua, Mirko de Melis, Christina Dimopoulou, Dobromir Dobrev, Christina Easter, Lars Eckardt, Doreen Haase, Stephane Hatem, Jeff S Healy | Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference. | EP Europace, 2021 | ISSN 1099-5129 | |
Jelena Kornej, Jared W Magnani, Sarah R Preis, Elsayed Z Soliman, Ludovic Trinquart, Darae Ko, Emelia J Benjamin, Honghuang Lin | P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study. | Heart Rhythm, 2021 | ISSN 1547-5271 | |
Jelena Kornej, Vanessa A Hanger, Ludovic Trinquart, Darae Ko, Sarah R Preis, Emelia J Benjamin, Honghuang Lin | New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation. | Cardiovasc Res, 2021 | ISSN 0008-6363 | |
Zink MD, Mischke KG, Keszei AP, Rummey C, Freedman B, Neumann G, Tolksdorf A, Frank F, Wienströer J, Kuth N, Schulz JB., Screen-detected atrial fibrillation predicts mortality in elderly subjects. | EP Europace. 2021 Jan 1;23(1):29-38. | |||
Alexander Rösler, Renate Schnabel.,Vorhofflimmern und kognitive Störung – Bedeutung für die Geriatrie. Zeitschrift für Gerontologie und Geriatrie, 2020 | ISSN 0948-6704 | |||
Giulia Renda, Ladislav Pecen, Giuseppe Patti, Fabrizio Ricci, Dipak Kotecha, Jolanta M. Siller-Matula, Renate B. Schnabel, Rolf Wachter, Jean-Marc Sellal, Miklos Rohla, Markus Lucerna, Kurt Huber, Freek W. A. Verheugt, Jose Luis Zamorano, Bernd Brüggenjürgen, Harald Darius, Mattias Duytschaever, Jean-Yves Le Heuzey, Richard J. Schilling, Paulus Kirchhof, Raffaele De Caterina | Antithrombotic management and outcomes of patients with atrial fibrillation treated with NOACs early at the time of market introduction: Main results from the PREFER in AF Prolongation Registry. | Internal and Emergency Medicine, 2020 | ISSN 1828-0447 | |
Renate B. Schnabel, Gert Hasenfuß, Sylvia Buchmann, Kai G. Kahl, Stefanie Aeschbacher, Stefan Osswald, Christiane E. Angermann | Heart and brain interactions. Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH | |||
Benedikt Schrage, Bastiaan Geelhoed, Teemu J. Niiranen, Francesco Gianfagna, Julie K. K. Vishram‐Nielsen, Simona Costanzo, Stefan Söderberg, Francisco M. Ojeda, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Augusto Di Castelnuovo, Stephan Camen, Jukka Kontto, Wolfgang Koenig, Stefan Blankenberg, Giovanni de Gaetano, Allan Linneberg, Torben Jørgensen, Tanja Zeller, Kari Kuulasm | Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death. Journal of the American Heart Association, Issue 9/9, 2020 | ISSN 2047-9980 |