AFFECT-EU Study

DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY

The AFFECT-EU project was initiated by Renate Schnabel a member of the AF-SCREEN steering committee, who was the Chief Investigator in the application for a Horizon-2020 EU grant which included many members of AF-SCREEN.

The project is an EU-funded consortium including 25 partner from academia and industry. AFFECT-EU`s major goal is the development of a risk-based, accurate, and ready for implementation atrial fibrillation screening algorithm, using digital devices, for early AF detection in the community. AFFECT-EU will fill in the AF screening knowledge gaps by integrating information from independent studies entering the project. These data will be used to implement a risk-based AF screening approach and to provide evidence on the superiority of AF screening using a robust community screening strategy for reducing AF-related morbidity and mortality

The AFFECT-EU

Coordinator: Renate Schnabel

University Medical Center Hamburg-Eppendorf (UKE)

Martinistraße 52, 20246 Hamburg, Germany

Authors Title Publication Pages ISSN
Schnabel RB, Ameri P, Siller-Matula JM, Diemberger I, Gwechenberger M, Pecen L, Manu MC, Souza J, De Caterina R, Kirchhof P. Outcomes of patients with atrial fibrillation on oral anticoagulation with and without heart failure: the ETNA-AF-Europe registry. Europace. 2023 Sep 15:euad280.
Sposato Luciano et al. Towards a new classification of atrial fibrillation detected after a stroke or a transient ischaemic attack. Lancet Neurology
Schnabel RB, Ameri P, Siller-Matula JM, Diemberger I, Gwechenberger M, Pecen L, Manu MC, Souza J, De Caterina R, Kirchhof P. Outcomes of patients with atrial fibrillation on oral anticoagulation with and without heart failure: the ETNA-AF-Europe registry. Europace. 2023 Sep 15:euad280.
Lucas Yixi Xing, Søren Zöga Diederichsen, Søren Højberg, Derk W Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S Olesen, Axel Brandes, Lars Køber, Ketil Jørgen Haugan, Jesper Hastrup Svendsen Effects of systematic atrial fibrillation screening according to N-terminal pro-B-type natriuretic peptide: a secondary analysis of the randomized LOOP study.
Xing, L.Y., Diederichsen, S.Z., Højberg, S., Krieger, D.W., Graff, C., Olesen, M.S., Nielsen, J.B., Brandes, A., Køber, L., Haugan, K.J., and Svendsen, J.H. Electrocardiographic Markers of Subclinical Atrial Fibrillation Detected by Implantable Loop Recorder: Insights from the LOOP Study. Europace , 2023
Börschel CS, Geelhoed B, Niiranen T, Camen S, Donati MB, Havulinna AS, Gianfagna F, Palosaari T, Jousilahti P, Kontto J, Vartiainen E, Ojeda FM, den Ruijter HM, Costanzo S, de Gaetano G, Di Castelnuovo A, Linneberg A, Vishram-Nielsen JK, Løchen ML, Koenig W, Jørgensen T, Kuulasmaa K, Blankenberg S, Iacoviello L, Zeller T, Söderberg S, Salomaa V, Schnabel RB. Risk prediction of atrial fibrillation and its complications in the community using hs troponin I. Eur. J. Clin. Invest., 2023 ISSN 0014-2972
Jelena Kornej, Honghuang Lin, Ludovic Trinquart, Corban R Jackson, Darae Ko, Emelia J Benjamin, Sarah R Preis Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study. J Am Heart Assoc, 2023 ISSN 2047-9980
Toprak B, Brandt S, Brederecke J, Gianfagna F, Vishram-Nielsen JKK, Ojeda FM, Costanzo S, Börschel CS, Söderberg S, Katsoularis I, Camen S, Vartiainen E, Donati MB, Kontto J, Bobak M, Mathiesen EB, Linneberg A, Koenig W, Løchen ML, Di Castelnuovo A, Blankenberg S, de Gaetano G, Kuulasmaa K, Salomaa V, Iacoviello L, Niiranen T, Zeller T, Schnabel RB. Exploring the incremental utility of circulating biomarkers for robust risk prediction of incident atrial fibrillation in European cohorts using regressions and modern machine learning methods. Europace, 2023 ISSN 1532-2092
Börschel CS, Ortega-Alonso A, Havulinna AS, Jousilahti P, Salmi M, Jalkanen S, Veikko S, Niiranen T, Schnabel RB. Inflammatory proteomics profiling for prediction of incident atrial fibrillation. Heart, 2023 ISSN 1355-6037
Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. Europace, 2023 ISSN 1099-5129
Sílvia C Mendonça, Duncan Edwards, Jenny Lund, Catherine Saunders and Jonathan Mant Progression of stroke risk in atrial fibrillation: cohort study in general practice. British Journal of General Practice, 2023 ISSN 0960-1643
Joonatan Palmu, Christin S. Börschel, Alfredo Ortega-Alonso, Lajos Markó, Mike Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel Gut microbiome and atrial fibrillation – results from a large population-based study. eBioMedicine, 2023 ISSN 2352-3964
Vermunicht P, Grecu M, Deharo JC, Buckley CM, Palà E, Mairesse GH, Farkowski MM, Bergonti M, Pürerfellner H, Hanson CL, Neubeck L. General practitioners’ perceptions on opportunistic single-time point screening for atrial fibrillation: A European quantitative survey. Frontiers in Cardiovascular Medicine. 2023 Feb 15;10:1112561.
Pecha, S., Ismaili, D., Geelhoed, B., Knaut, M., Reichenspurner, H., Eschenhagen, T., Schnabel, R. B., Christ, T., & Ravens, U.., (2023). Resting membrane potential is less negative in trabeculae from right atrial appendages of women, but action potential duration does not shorten with age. Journal of Molecular and Cellular Cardiology, VOLUME 176, P1-10, MARCH 2023
Xing, L. Y., Diederichsen, S. Z., Højberg, S., Krieger, D. W., Graff, C., Olesen, M. S., … & Svendsen, J. H. (2022) Screening for atrial fibrillation to prevent stroke in elderly individuals with or without preexisting cardiovascular disease: A post hoc analysis of the randomized LOOP study. International Journal of Cardiology 370, 197-203.
Diederichsen SZ, Frederiksen KS, Xing LY, et al. Severity and Etiology of Incident Stroke in Patients Screened for Atrial Fibrillation vs Usual Care and the Impact of Prior Stroke: A Post Hoc Analysis of the LOOP Randomized Clinical Trial. Jama Neurology, 2022;79(10):997–1004
McIntyre W.F. et al Screening for atrial fibrillation to prevent stroke: a meta-analysis. European Heart Journal, Volume 2, Issue 4, July 2022
Xing LY, Diederichsen SZ, Højberg S, Krieger DW, Graff C, Olesen MS, Brandes A, Køber L, Haugan KJ, Svendsen JH. Systolic Blood Pressure and Effects of Screening for Atrial Fibrillation With Long-Term Continuous Monitoring (a LOOP Substudy). Hypertension, 2022;79:2081–2090
Palà E, Bustamante A, Pagola J, Juega J, Francisco-Pascual J, Penalba A, Rodriguez M, De Lera Alfonso M, Arenillas JF, Cabezas JA, Pérez-Sánchez S. Blood-Based Biomarkers to Search for Atrial Fibrillation in High-Risk Asymptomatic Individuals and Cryptogenic Stroke Patients. Frontiers in cardiovascular medicine, 2022 Jul 4;9:908053
Engler D, Hanson CL, Desteghe L, Boriani G, Diederichsen SZ, Freedman B, Palà E, Potpara TS, Witt H, Heidbuchel H, Neubeck L. Feasible approaches and implementation challenges to atrial fibrillation screening: a qualitative study of stakeholder views in 11 European countries. the BMJ open, 2022 Jun 1;12(6):e059156.
Ohlrogge AH, Brederecke J, Ojeda FM, Pecha S, Börschel CS, Conradi L, Rimkus V, Blankenberg S, Zeller T, Schnabel RB. The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study. Frontiers in Nutrition. 2022 May 10;9
Valenti AC, Albini A, Imberti JF, Vitolo M, Bonini N, Lattanzi G, Schnabel RB, Boriani G. Clinical Profile, Arrhythmias, and Adverse Cardiac Outcomes in Emery-Dreifuss Muscular Dystrophies: A Systematic Review of the Literature. Biology. 2022 Mar 30;11(4):530.
Rivard L, Friberg L, Conen D, Healey JS, Berge T, Boriani G, Brandes A, Calkins H, Camm AJ, Yee Chen L, Lluis Clua Espuny J. Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration. Circulation
Assum I, Krause J, Scheinhardt MO, Müller C, Hammer E, Börschel CS, Völker U, Conradi L, Geelhoed B, Zeller T, Schnabel RB Tissue-specific multi-omics analysis of atrial fibrillation. Nature
Sarah Hoare, Alison Powell, Rakesh Modi, Natalie Armstrong, Simon Griffin, Jonathan Mant, Jenni Burt Why do people take part in atrial fibrillation screening? Qualitative interview study in English primary care. BMJ Open, 2022 ISSN 2044-6055
Aittokallio J, Kauko A, Vaura F, Salomaa V, Kiviniemi T; FinnGen; Schnabel RB, Niiranen T. Polygenic Risk Scores for Predicting Adverse Outcomes After Coronary Revascularization. Am. J. Cardiol., 2022 ISSN 0002-9149
Camen S, Csengeri D, Geelhoed B, Niiranen T, Gianfagna F, Vishram-Nielsen JK, Costanzo S, Söderberg S, Vartiainen E, Börschel CS, Donati MB, Løchen ML, Ojeda FM, Kontto J, Mathiesen EB, Jensen S, Koenig W, Kee F, de Gaetano G, Zeller T, Jørgensen T, Tunstall-Pedoe H, Blankenberg S, Kuulasmaa K, Linneberg A, Salomaa V, Iacoviello L, Schnabel RB. Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation. J. Am. Heart Assoc., 2022 ISSN 2047-9980
Oskarsson V, Eliasson M, Salomaa V, Reinikainen J, Männistö S, Palmieri L, Donfrancesco C, Sans S, Costanzo S, de Gaetano G, Iacoviello L, Veronesi G, Ferrario MM, Padro T, Thorand B, Huth C, Zeller T, Blankenberg S, Anderson AS, Tunstall-Pedoe H, Kuulasmaa K, Söderberg S; BiomarCaRE investigators. Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. Br J Nutr, 2022 ISSN 0007-1145
Jelena Kornej, Maha A Qadan, Mona Alotaibi, David R Van Wagoner, Jeramie D Watrous, Ludovic Trinquart, Sarah R Preis, Darae Ko, Mohit Jain, Emelia J Benjamin, Susan Cheng, Honghuang Lin The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study. Scientific Reports, 2022 ISSN 2045-2322
Rosberg V, Vishram-Nielsen JK, Kristensen AMD, Pareek M, Sehested TSG, Nilsson PM, Linneberg A, Palmieri L, Giampaoli S, Donfrancesco C, Kee F, Mancia G, Cesana G, Veronesi G, Grassi G, Kuulasmaa K, Salomaa V, Palosaari T, Sans S, Ferrieres J, Dallongeville J, Söderberg S, Moitry M, Drygas W, Tamosiunas A, Peters A, Brenner H, Schöttker B, Grimsgaard S, Biering-Sørensen T, Olsen MH. Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project. Prev Med Rep, 2022 ISSN 2211-3355
Alison Powell, Sarah Hoars, Rakesh Modi, Kate Williams, Andrew Dymond, Cheryl Chapman, Simon Griffon, Jonathan Mant, Jenni Burt How to embed qualitative research in trials: insights from the feasibility study of the SAFER trial programme. Trials, 2022 ISSN 1745-6215
Kate Williams, Rakesh Modi, Andrew Dymond, Sarah Hoare. Alison Powell, Jenni Burt, Duncan Edwards, Jenny Lund, Rachel Johnson, Trudie Lobban, Mark Lown, Michael Sweeting, H Thom, Stephen Kaptoge, Francesco Fusco, Stephen Morris, Gregory Lip, Natalie Armstrong, Martin Cowie, David Fitzmaurice, Ben Freedman, Simon Griffin, Stephen Sutton, Richard Hobbs, Richard McManus, Jonathan Mant Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial. BMJ Open, 2022 ISSN 2044-6055
Rehm M, Rothenbacher D, Iacoviello L, Costanzo S, Tunstall-Pedoe H, Fitton CA, Söderberg S, Hultdin J, Salomaa V, Jousilahti P, Palosaari T, Kuulasmaa K, Waldeyer C, Schnabel RB, Zeller T, Blankenberg S, Koenig W; BiomarCaRE Consortium Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project. ESC Heart Fail., 2022 ISSN 0195-668X
Sujana C, Salomaa V, Kee F, Seissler J, Jousilahti P, Neville C, Then C, Koenig W, Kuulasmaa K, Reinikainen J, Blankenberg S, Zeller T, Herder C, Mansmann U, Peters A, Thorand B; BiomarCaRE Consortium. Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium. Cardiovascular Diabetology, 2022 ISSN 1475-2840
ESC Cardiovasc Risk Collaboration, SCORE2 Working Group. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal. 2021 Jul 1;42(25):2439-54.
Dora Csengeri, Ngoc-Anh Sprünker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Steen M Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Løchen, Frank Kee, Jukka Kontto, Ellisiv B Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jørgensen, Kari K Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes. European Heart Journal, 2021 ISSN 0195-668X
Christin S Börschel, Amelie H Ohlrogge, Bastiaan Geelhoed, Teemu Niiranen, Aki S Havulinna, Tarja Palosaari, Pekka Jousilahti, Michiel Rienstra, Pim van der Harst, Stefan Blankenberg, Tanja Zeller, Veikko Salomaa, Renate B Schnabel Risk prediction of atrial fibrillation in the community combining biomarkers and genetics. EP Europace, 2021 ISSN 1099-5129
Vuori MA, Reinikainen J, Söderberg S, Bergdahl E, Jousilahti P, Tunstall-Pedoe H, Zeller T, Westermann D, Sans S, Linneberg A, Iacoviello L, Costanzo S, Salomaa V, Blankenberg S, Kuulasmaa K, Niiranen TJ. Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM/BiomarCaRE consortium. Cardiovascular Diabetology, 2021 ISSN 1475-2840
Daniel Engler, Hein Heidbuchel, Renate B Schnabel Digital, risk-based screening for atrial fibrillation in the European community—the AFFECT-EU project funded by the European Union. European Heart Journal, 2021 ISSN 0195-668X
Sujana C, Salomaa V, Kee F, Costanzo S, Söderberg S, Jordan J, Jousilahti P, Neville C, Iacoviello L, Oskarsson V, Westermann D, Koenig W, Kuulasmaa K, Reinikainen J, Blankenberg S, B; BiomarCaRE Consortium. Zeller T, Herder C, Mansmann U, Peters A, Thorand Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium. Diabetes Care, 2021 ISSN 0149-5992
Ben Freedman, Gerhard Hindricks, Amitava Banerjee, Adrian Baranchuk, Chi Keong Ching, Xin Du, Donna Fitzsimons, Jeff S. Healey, Takanori Ikeda, Trudie C. A. Lobban, Amam Mbakwem, Calambur Narasimhan, Lis Neubeck, Peter Noseworthy, Daniel M. Philbin, Fausto J. Pinto, Joselyn Rwebembera, Renate B. Schnabel, Jesper Hastrup Svendsen, Luis Aguinaga, Elena Arbelo, Michael Böhm, Hasan Ali Farhan, F. D. World Heart Federation Roadmap on Atrial Fibrillation – A 2020 Update. Global Heart, Issue 16/1, 2021 ISSN 2211-8179
Larissa Fabritz, Harry J G M Crijns, Eduard Guasch, Andreas Goette, Karl Georg Häusler, Dipak Kotecha, Thorsten Lewalter, Christian Meyer, Tatjana S Potpara, Michiel Rienstra, Renate B Schnabel, Stephan Willems, Guenter Breithardt, A John Camm, Anthony Chan, Winnie Chua, Mirko de Melis, Christina Dimopoulou, Dobromir Dobrev, Christina Easter, Lars Eckardt, Doreen Haase, Stephane Hatem, Jeff S Healy Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference. EP Europace, 2021 ISSN 1099-5129
Jelena Kornej, Jared W Magnani, Sarah R Preis, Elsayed Z Soliman, Ludovic Trinquart, Darae Ko, Emelia J Benjamin, Honghuang Lin P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study. Heart Rhythm, 2021 ISSN 1547-5271
Jelena Kornej, Vanessa A Hanger, Ludovic Trinquart, Darae Ko, Sarah R Preis, Emelia J Benjamin, Honghuang Lin New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation. Cardiovasc Res, 2021 ISSN 0008-6363
Zink MD, Mischke KG, Keszei AP, Rummey C, Freedman B, Neumann G, Tolksdorf A, Frank F, Wienströer J, Kuth N, Schulz JB., Screen-detected atrial fibrillation predicts mortality in elderly subjects. EP Europace. 2021 Jan 1;23(1):29-38.
Alexander Rösler, Renate Schnabel.,Vorhofflimmern und kognitive Störung – Bedeutung für die Geriatrie. Zeitschrift für Gerontologie und Geriatrie, 2020 ISSN 0948-6704
Giulia Renda, Ladislav Pecen, Giuseppe Patti, Fabrizio Ricci, Dipak Kotecha, Jolanta M. Siller-Matula, Renate B. Schnabel, Rolf Wachter, Jean-Marc Sellal, Miklos Rohla, Markus Lucerna, Kurt Huber, Freek W. A. Verheugt, Jose Luis Zamorano, Bernd Brüggenjürgen, Harald Darius, Mattias Duytschaever, Jean-Yves Le Heuzey, Richard J. Schilling, Paulus Kirchhof, Raffaele De Caterina Antithrombotic management and outcomes of patients with atrial fibrillation treated with NOACs early at the time of market introduction: Main results from the PREFER in AF Prolongation Registry. Internal and Emergency Medicine, 2020 ISSN 1828-0447
Renate B. Schnabel, Gert Hasenfuß, Sylvia Buchmann, Kai G. Kahl, Stefanie Aeschbacher, Stefan Osswald, Christiane E. Angermann Heart and brain interactions. Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
Benedikt Schrage, Bastiaan Geelhoed, Teemu J. Niiranen, Francesco Gianfagna, Julie K. K. Vishram‐Nielsen, Simona Costanzo, Stefan Söderberg, Francisco M. Ojeda, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Augusto Di Castelnuovo, Stephan Camen, Jukka Kontto, Wolfgang Koenig, Stefan Blankenberg, Giovanni de Gaetano, Allan Linneberg, Torben Jørgensen, Tanja Zeller, Kari Kuulasm Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death. Journal of the American Heart Association, Issue 9/9, 2020 ISSN 2047-9980